[Etude] 01/02/13 - innocuité à court terme de la vapeur inhalée - ( Dr. Andreas Flouris "Acute impact of active and passive electronic cigarette smoking on serum cotinine and lung function"(+commentaires M.Siegel))

Le Professeur Michael Siegel, maintes fois présenté ici (Prof. Au Département des Sciences de la sante à l’Université de Boston, enseignant en sciences sociales, comportementales, communication et santé publique, 25 années de recherches et d’études dans le domaine du tabagisme actif et passif et de la lutte anti-tabac, témoin dans le procès historique Engle contre les compagnies de tabac) a fait récemment mention [1] d'une étude [2] démontrant que le vapotage (inhalation de vapeur produite par la cigarette électronique) n’avait aucun effet négatif ou indésirable sur les capacités pulmonaires des sujets adultes qui s’étaient prêtés à cette étude.

Andreas D. Flouris¹, Maria S. Chorti^1,2,3, Konstantina P. Poulianiti², Athanasios Z. Jamurtas², Konstantinos Kostikas⁴, Manolis N. Tzatzarakis⁵, A. Wallace Hayes⁵, Aristidis M. Tsatsakis⁶, and Yiannis Koutedakis^1,2,7


6. School of Public Health, Harvard University,Boston

Acute impact of active and passive electronic cigarette smoking on serum cotinine and lung function
February 2013



Abstract
Context: Electronic cigarettes (e-cigarettes) are becoming increasingly popular yet their effects on health remain unknown.
Objective: To conduct the first comprehensive and standardized assessment of the acute impact of active and passive e-cigarette smoking on serum cotinine and lung function, as compared to active and passive tobacco cigarette smoking.
Materials and methods: Fifteen smokers (≥15 cigarettes/day; seven females; eight males) and 15 never-smokers (seven females; eight males) completed this repeated-measures controlled study. Smokers underwent a control session, an active tobacco cigarette (their favorite brand) smoking session and an active e-cigarette smoking session. Never-smokers underwent a control session, a passive tobacco cigarette smoking session and a passive e-cigarette smoking session. Serum cotinine, lung function, exhaled carbon monoxide and nitric oxide were assessed. The level of significance was set at p ≤ 0.001 to adjust for multiple comparisons.
Results: e-Cigarettes and tobacco cigarettes generated similar (p  > 0.001) effects on serum cotinine levels after active (60.6 ± 34.3 versus 61.3 ± 36.6 ng/ml) and passive (2.4 ± 0.9 versus 2.6 ± 0.6 ng/ml) smoking. Neither a brief session of active e-cigarette smoking (indicative: 3% reduction in FEV1/FVC) nor a 1 h passive e-cigarette smoking (indicative: 2.3% reduction in FEV1/FVC) significantly affected the lung function (p > 0.001). In contrast, active (indicative: 7.2% reduction in FEV1/FVC; p < 0.001) but not passive (indicative: 3.4% reduction in FEV1/FVC; p = 0.005) tobacco cigarette smoking undermined lung function.
Conclusion: Regarding short-term usage, the studied e-cigarettes generate smaller changes in lung function but similar nicotinergic impact to tobacco cigarettes. Future research should target the health effects of long-term e-cigarette usage, including the effects of nicotine dosage.



Read More: http://informahealthcare.com/doi/abs/10.3109/08958378.2012.758197